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Doctor's Best, SAM-e, 200 mg, 60 Enteric Coated Tablets

Item # : 1705
Manufacturer SKU : 753950002067
Product Code : DB0206
Package Details : 60 Enteric Coated Tablets
Serving Size : 1 tablet
Serving per Container : This bottle will last for 60 Days
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Doctor's Best, SAM-e, 200 mg, 60 Enteric Coated Tablets
Price(र)  : 12595.00

Ships in 4 weeks


•   Science-Based Nutrition
•   Pharmaceutical Grade
•   Dietary Supplement With 200 mg Active S-Adenosyl Methionine Per Tablet
•   Enhances Mood & Neural Function
•   Promotes Joint Comfort & Mobility
•   Supports Liver Health & Detoxification
•   Vegan
•   Sealed in Blister Packs for Freshness & Convenience


Our SAMe 200 contains 200 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.
S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissues including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMe
The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in our SAMe 200 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint Function
SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural Health
SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver Function
SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.

Suggested Use:

Take 1 tablet daily away from food, or as directed by a health care professional. Do not chew or crush tablet.


Supplement Facts:

Serving Size: 1 tablet

Servings Per Container: 60 servings


Amount Per Serving

% Daily Value

S-Adenosyl Methionine (from 400 mg of SAM-e tosylate disulfate)

200 mg

† Daily Value not established.


Other Ingredients:

Cellulose gel, methacrylic acid copolymer, compritol 888ATO, talc, triethyl citrate, titanium dioxide, magnesium stearate, mannitol, glycerol palmitostearate, silica, medium chain triglycerides, sodium starch glycolate and iron oxide.

The SAMe found in Doctor's Best SAMe 200 mg is free from yeast, dairy, gluten, soy, wheat and artificial flavoring.

Contains nothing other than listed ingredients.


Individuals using antidepressant medications should consult with their prescribing physician prior to using this product. Individuals diagnosed with bipolar disease or manic depression should avoid supplementing with SAMe. Do not use if pregnant or nursing. May cause gastrointestinal discomfort in a small percentage of people.

SAMe 200 is sealed in blister packs for freshness and stability.

Store product in a cool, dry place to ensure maximum quality.

Q.What is SAMe?
A.S-Adenosylmethionine (SAMe) is a naturally occurring compound that is found in almost every tissue and fluid in the body. It is involved in many important processes. SAMe plays a role in the immune system, maintains cell membranes, and helps produce and break down brain chemicals, such as serotonin, melatonin, and dopamine. It works with vitamin B12 and folate (vitamin B9). Being deficient in either vitamin B12 or folate may reduce levels of SAMe in your body.

Q.How does it work?
A.The body uses SAMe to make certain chemicals in the body that play a role in pain, depression, liver disease, and other conditions. People who don’t make enough SAMe naturally may be helped by taking SAMe as a supplement.

Q.What are Dietary Sources of SAMe?
A.SAMe is not found in food. It is produced by the body from ATP and the amino acid methionine. (ATP serves as the major energy source for cells throughout the body).

Q.What are healthy benefits of SAMe?
A.Healthy benefits of SAMe are:
SAMe is more effective than placebo in treating mild-to-moderate depression and is just as effective as antidepressant medications without the side effects (headaches, sleeplessness, and sexual dysfunction). In addition, antidepressants tend to take 6 - 8 weeks to begin working, while SAMe seems to begin more quickly.
SAMe may reduce pain and inflammation in the joints, and researchers think it may also promote cartilage repair. SAMe supplements were as effective as nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen and naproxen in adults with knee, hip, or spine osteoarthritis. SAMe has fewer side effects than NSAIDs. 
SAMe can be effective in reducing symptoms of fibromyalgia -- including pain, fatigue, morning stiffness, and depressed mood.A dose of SAMe by mouth found effective at reducing these symptoms
Liver Disease
People with liver disease often cannot synthesize SAMe in their bodies and SAMe may help treat chronic liver disease caused by medications or alcoholism. SAMe may help normalize levels of liver enzymes in people with liver disease. 

Q.What are side effects of SAMe?
A.SAMe is safe for most people. It can sometimes cause gas, vomiting, diarrhea, constipation, dry mouth, headache, mild insomnia, anorexia, sweating, dizziness, and nervousness, especially at higher doses. It can make some people with depression feel anxious.

Q.Can I Take SAMe & 5-HTP at the Same Time?
A.No, it should not to be taken at same time.SAMe and 5-HTP are chemicals produced naturally within the human body. Both have been studied for use in depression for many decades.The combination of 5-HTP and SAM-e is harmful