Many clinicians are now utilizing higher doses of Trimethylglycine (TMG). For individuals whose doctors recommend these higher dosages, Kirkman offers a 500 mg TMG capsule that will minimize the number of capsules needed to meet the physicians’ recommended intake.  This is a hypoallergenic formulation, specially designed for individuals with special requirements and sensitivities.

Kirkman’s TMG is derived from beets, which is the commercially available source. TMG is dimethylglycine (DMG) with one more methyl group.  The chemical structure of TMG is a glycine molecule holding onto three methyl groups.  Like DMG, TMG is considered a "methyl donor" or “methyl bank."  The additional methyl group makes TMG a more active methyl donor than DMG, which provides a benefit to some individuals.  TMG can support the formation of methionine by methylating homocysteine.  Some of this methionine eventually is converted into SAMe (S-adenosylmethionine), which can help maintain healthy serotonin levels in the body, thus supporting mood and a feeling of well-being. 

As with DMG, TMG plus a coenzyme of riboflavin supplies methyl groups that attach to folic acid to form methylene tetrahydrofolate, an important component of many biochemical processes in the body including cellular perception and response.

Kirkman also produces this product with folinic acid and vitamin B-12; however, some physicians would rather use the product in its pure form and supplement with other ratios of folinic acid and vitamin B-12.