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DMG
Overview
Dimethylglycine is an amino acid, a building block for protein. It is found in the body in very small amounts and for only seconds at a time. People use dimethylglycine to make medicine.

Dimethylglycine is used for attention deficit-hyperactivity disorder (ADHD), epilepsy, chronic fatigue syndrome (CFS), allergies, respiratory disorders, pain and swelling (inflammation), cancer, alcoholism, and drug addiction. It is also used to improve speech and behavior in autism, nervous system function, liver function, the body’s use of oxygen, and athletic performance. Some people use it to reduce stress and the effects of aging, as well as boost the immune system’s defenses against infection. Dimethylglycine is also used to lower blood cholesterol and triglycerides, and to help bring blood pressure and blood sugar into normal range.

In the 1980s, a federal court in Chicago banned the interstate sale of a brand of dimethylglycine, stating that it was an unsafe food additive.

Dimethylglycine might help improve the way the body's immune system works.


What is DMG?
Dimethyl Glycine, a by-product of choline-to-glycine metabolization, is a building block for the synthesis of methionine, choline, and important hormones, neurotransmitters, and DNA. The body produces DMG in small amounts. DMG helps to improve mental activity, produce high energy levels, and maintain immune system health. It also enhances oxygenation and organic function.

DMG, while considered a food, is also a derivative of glycine, absorbed in the small intestines and transported to the liver, where it is metabolized and converted to glycine. DMG is formed from trimethylglycine or betaine, and DMG not metabolized is transported to other parts of the body.

Those that could be at risk for DMG deficiency include, because the medication could reduce the body’s absorption off DMG, anyone taking prescription medications. These people may benefit more than others from DMG supplementation. Alcoholics, too, because they tend to eat poorly, are at risk. Alcoholic beverages block the absorption, and increase the excretion, of many nutrients; this makes increase the need for DMG supplementation. Those with degenerative diseases including lung disease, and diabetes, may inadequately absorb, or excessively excrete, many essential, nutrients. They are good candidates for nutritional supplementation, and should be under a doctor’s care.

Both those who experience cardiac problems, and coffee drinkers, because caffeine blocks DMG absorption, might benefit from extra DMG. DMG greatly improves the nutritional environment of the cell. Dimethylglycine has been found to be effective in enhancing the body's immune system.

DMG reduces lactic acid build up in the muscle thereby shortening recovery time after strenuous exercise and improving endurance. DMG can benefit everyone regardless of age or activity level.


Where it is found
Dimethylglycine (DMG) is an amino acid found naturally in plant and animal cells. It can be found in beans and liver.

Benefits / uses
Cardiovascular Disease: Decreases elevated triglyceride and cholesterol levels. Improves circulation, helps the body adapt to stress, decreases homocysteine levels, increases glutathione and SAMe.

Cancer: DMG has anti-tumor properties, modulates the immune system, and helps protect DNA.

Diabetes: DMG regulates sugar metabolism, helps production of hormones like insulin, helps with cataract prevention, and acts as an antioxidant.

Immune System: Enhances the immune system by acting as an anti-viral, anti-bacterial, and anti-fungal agent.
 
Athletic Performance: Increases oxygen utilization, decreases lactic acid formation, and makes energy production more efficient.

Autism: DMG acts as a methyl donor, adaptogen, as well as impacting the immune response, and enhancing neurotransmitter production.

Alcoholism/Drug Addictions: DMG eliminates craving for drugs and alcohol, as well as helping to detoxify the liver.

Neurological Disorders: DMG reduces seizures frequency and strength, increases circulation, provides building blocks to important neurotransmitters and hormones, and makes energy production more efficient.

Respiratory problems: DMG increases circulation, increases oxygen utilization, decreases lactic acid, and acts as an adaptogen.

Liver and Kidney Disorders: DMG acts as a methyl donor, it enhances circulation, enhances glutathione and SAMe producrtion, and has lipotropic properties.

Stress: DMG acts as an adaptogen and helps the body cope with physical, emotional and metabolic stress, acts as an antioxidant, provides building blocks, increases oxygen utilization, decreases lactic acid, and helps modulate the immune system.

Autoimmune Diseases (like Lupus): DMG modulates the immune response in those with autoimmune diseases.

Cataract Prevention: DMG’s increases circulation, rids the area of optical debris, enhances oxygen utilization at a cellular level, and acts as an antioxidant.

Chronic Fatigue Syndrome/Fibromyalgia: DMG enhances oxygen utilization, improves circulation, makes energy production more efficient, modulates the immune system, and decreases lactic acid levels.

Degenerative Diseases/Arthritis: DMG has anti-inflammatory properties and supports the immune system.

General health/Premature Aging: DMG modulates the immune system, increases circulation, improves oxygen utilization, and acts as an adaptogen and provides building blocks needed for synthesis of important body constituents. Research also suggest that DMG is beneficial in the healing of skin disorders, circulatory insufficiencies, epilepsy, migraines, tension headaches, vascular headaches, autoimmune diseases, asthma, and allergies.

Doses
The appropriate dose of dimethylglycine depends on several factors such as the user's age, health, and several other conditions

Possible Side effects / Precautions / Possible Interactions:
Dimethylglycine might be safe to use short-term, up to 28 days. The safety of long-term use is unknown.

Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of dimethylglycine during pregnancy and breast-feeding. Stay on the safe side and avoid use.

References:
arw Bishop, P. A., Smith, J. F. and Young, B. (1987) Effects of N' N'-dimethylglycine on physiological response and performance in trained runners. J Sports Med Phys Fitness. 27, 53.
arw Harpaz, M., Otto, R. M. and Smith, T. K. (1985) The effect of N' N'-dimethylglycine ingestion upon aerobic performance. Med Sci Sports Exerc. 17, 287.
arw Liet, J. M., Pelletier, V., Robinson, B. H., Laryea, M. D., Wendel, U., Morneau, S., Morin, C., Mitchell, G. and Lacroix, J. (2003) The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomised crossover clinical trial. J Pediatr. 142 (1), 62-66.
arw Reap, E. A. and Lawson, J. W. (1990) Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. 115 (4), 481-486.
arw Rose, R. J. Schlierf, H. A., Knight, P. K., Plummer, C., Davis, M. and Ray, S. P. (1989) Effects of N,N-dimethylglycine on cardiorespiratory function and lactate production in thoroughbred d horses performing incremental treadmill exercise. Vet Rec. 125 (10), 268-271.
arw Tonda, M. E. and Hart, L. L. (1992) N,N dimethylglycine and L-carnitine as performance enhancers in athletes. Annals of Pharmacotherapy. 26, 935-937.