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Ipriflavone
Overview
Ipriflavone is made in the laboratory from another substance (daidzein) that is taken from soy. Soy is a plant.
Ipriflavone is used for preventing and treating weak bones (osteoporosis) in older women, preventing osteoporosis caused by certain medications, relieving pain associated with osteoporosis, and treating a bone disease called Paget's disease. It is also used for reducing bone loss caused by chronic kidney disease (renal osteodystrophy) and by paralysis associated with stroke. Researchers have found that paralyzed stroke patients have weaker bones on the affected side, possibly due to immobility as well as vitamin D deficiency. Vitamin D deficiency may stem from lack of exposure to sunlight.
Ipriflavone is also used by bodybuilders to increase metabolism. Ipriflavone may prevent bone strength loss, and help improve the effects of estrogen in preventing osteoporosis. When used in combination with estrogens, it might allow lower estrogen doses to be used in postmenopausal women.


What is Ipriflavone?
Ipriflavone is a synthetic isoflavone which may be used to inhibit bone resorption, maintain bone density and to prevent osteoporosis in postmenopausal women. It is not used to treat osteoporosis. It slows down the action of the osteoclasts (bone-eroding cells), possibly allowing the osteoblasts (bone-building cells) to build up bone mass.

How it is made
Ipriflavone is a substance man-made in the laboratory from another substance (daidzein) that is derived from soy.

Where it is found
Ipriflavone does occur naturally in food but only in trace amounts. It is available as a nutritional supplement.

Benefits / uses
arw Treating and preventing weak bones (osteoporosis) in postmenopausal women. Taking ipriflavone in combination with 1000 mg of calcium daily can prevent loss of bone mineral density (BMD) in postmenopausal women with osteoporosis or low bone strength. There is some evidence that it might actually increase bone strength in some of these women. The effect seems to be determined by the amount of calcium that is taken along with the ipriflavone. One study using ipriflavone with only 500 mg per day of calcium found no effect on bone strength. But taking more than 1000 mg of calcium daily may increase the benefit.
arw Taking ipriflavone in combination with estrogen also seems to prevent osteoporosis and increase bone strength in older women. Adding calcium makes the combination work even better.
arw Reducing pain associated with osteoporosis. Ipriflavone can also significantly reduce pain due to osteoporosis and seems to be as effective as inhaling a medication called calcitonin.
arw Reducing bone loss in people who have been paralyzed on one side of their body by stroke (hemiplegic stroke).
arw Ipriflavone in combination with vitamin D seems to prevent bone loss significantly better than vitamin D alone in hemiplegic stroke patients with vitamin D deficiency.
arw Bone pain in people with Paget's disease.
arw Bone disease due to chronic kidney disease (renal osteodystrophy).
arw Increasing metabolism in bodybuilders.
 
Doses
arw For weak bones after menopause (postmenopausal osteoporosis): 200 mg of ipriflavone three times daily.
arw For a bone disorder called Paget's disease: 600-1200 mg of ipriflavone daily.
arw For treating weak bones due to kidney disease (renal osteodystrophy): 400-600 mg of ipriflavone daily.
 
Possible Side effects / Precautions / Possible Interactions:
Ipriflavone is LIKELY SAFE for most people when used with proper medical supervision. It can cause side effects such as stomach pain, diarrhea, or dizziness.
There is some concern that ipriflavone can cause a decreased white cell count (lymphocytopenia) in people taking it for greater than six months. White cell counts should be monitored, especially in people taking ipriflavone long-term.


Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of ipriflavone during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Weak immune system: Ipriflavone can lower the body’s white cell count, making it more difficult for the body to fight off infection. This is be especially concerning in people who already have a weak immune system due to AIDS, drugs used to prevent organ rejection after transplant, chemotherapy, or other causes. If you have a weak immune system, check with your healthcare provider before starting ipriflavone.

Low white cell count (lymphocytopenia): Since ipriflavone can cause lymphocytopenia, there is a concern that it might make pre-existing lymphocytopenia worse.

Interaction:
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with IPRIFLAVONE

Some medications are changed and broken down by the liver.

Ipriflavone might decrease how quickly the liver breaks down some medications. Taking ipriflavone along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking ipriflavone talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.


Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates) interacts with IPRIFLAVONE

Some medications are changed and broken down by the liver.

Ipriflavone might decrease how quickly the liver breaks down some medications. Taking ipriflavone along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking ipriflavone talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.


Medications that decrease the immune system (Immunosuppressants) interacts with IPRIFLAVONE

Ipriflavone might decrease the immune system. Taking ipriflavone along with other medications that decrease the immune system might decrease the immune system too much. Avoid taking ipriflavone with medications that decrease the immune system.

Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.


Theophylline interacts with IPRIFLAVONE
The body breaks down theophylline to get rid of it. Ipriflavone might decrease how quickly the body gets rid of theophylline. Taking ipriflavone along with theophylline might increase the effects and side effects of theophylline.

Reference& Research
arw Murray M & Pizzorno ND: Encyclopedia of Natural Medicine (2nd ed). Prima Press, Rocklin, CA; 1998.
arw Brandi ML: new treatment strategies: Ipriflavone, Strontium, Vitamin D Metabolites and Analogs. Am J Med 1993; 95(Suppl.5A): 69S-74S.
arw Moscarini M,Patacchiola F, Spacca G et al: New Perspective in the treatment of Postmenopausal Osteoporosis - Ipriflavone. Gynecol Endocrinol 1994; 8:203-207.
arw Passeri M, Biondi M, Costi D et al: Effect of ipriflavone on bone mass in elderly osteoporotic women. Bone Miner 1992;19(supp1):S57-S62.
arw Agnusdei D, Crepaldi G, Isaia et al: A double blind placebo-controlled trial of Ipriflavone for prevention of postmenopausal spinal bone loss. Calcif Tissue Int 1997;61:142-147.
arw Agnusdei D, Zacchei F, Bigazzi S et al: Metabolic and clinical effects of ipriflavone in established postmenopausal osteoporosis. Drugs Exp Clin Res 1989; 15(2):97-104.
arw Takahashi J, Kawakatsu K, Wakayama T et al: Elevation of serum theophylline levels by ipriflavone in a patient with chronic obstructive pulmonary disease. Eur J Clin Pharmacol 1992; 43:207-208.
arw Shino M: Pharmacokinetic study of ipriflavone by oral administration in healthy male volunteers. Jpn Pharmacol Ther 1985; 13:235.
arw Ju YH, Doerge DR, Allred KF et al: Dietary genestein negates the inhibitory effect of tamoxifen on growth of estrogen-dependent human breast cancer (MCF-7) cells implanted in athymic mice. Cancer Res 2002; 62(9):2474-2477.