Arginine Alpha-Ketoglutarate (AAKG) Overview

What is AAKG?

L-Arginine Alpha-Ketoglutarate (AAKG) is a compound made by combining:

• Two molecules of L-arginine (an amino acid)

• One molecule of alpha-ketoglutarate (a key intermediate in the Krebs cycle)

It is widely used in sports nutrition due to its role in promoting nitric oxide (NO) production, which enhances blood flow and muscle nutrient delivery.

How AAKG Works

• L-Arginine: Precursor to nitric oxide (a vasodilator), helping to increase blood flow and muscle pump during workouts.

• Alpha-Ketoglutarate: Supports amino acid metabolism, reduces ammonia toxicity, and improves protein utilization, especially in medical and athletic settings.

Primary Benefits

• Enhances muscle "pump" during workouts by increasing blood volume to muscles

• Improves nutrient and oxygen delivery to muscle tissue

• Supports protein synthesis and reduces muscle breakdown (catabolism)

• May boost amino acid metabolism, particularly glutamine and arginine

• Helps athletes and bodybuilders with arginine deficiency during intense training

• Can be combined with Creatine Ethyl Ester (CEE) for synergistic muscle-building effects

Medical Uses of Alpha-Ketoglutarate

• Kidney disease support

• Liver conditions, yeast infections, and gut health

• Used in IV form to prevent heart or muscle damage during surgeries

Natural Sources

• Found in nuts, seeds (e.g., peanuts, almonds), dairy, and chocolate

Recommended Dosage

• Typical dose: 500 mg to 1000 mg, 1–3 times daily

• Higher doses: Used by bodybuilders under professional guidance

• Use Limit: Not advised for continuous, high-level use beyond 80 days

Side Effects & Precautions

• Generally considered safe

• Possible side effects with overuse:

  • Stomach upset

  • Restlessness

  • Insomnia (especially if taken close to bedtime — avoid within 4–6 hours before sleep)

• Consult a healthcare provider if using with other supplements or medications